Design and synthesis of solid-supported reagents and their use in multi-step synthesis
Solid-supported reagents are being developed as a complementary technique to solid-phase organic synthesis. They offer the advantages of conducting clean chemistry with rapid purification of products and ease of reaction monitoring. This thesis describes the development of a solid-support bisdihydro...
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University of Cambridge
2002
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604989 |
| Summary: | Solid-supported reagents are being developed as a complementary technique to solid-phase organic synthesis. They offer the advantages of conducting clean chemistry with rapid purification of products and ease of reaction monitoring. This thesis describes the development of a solid-support bisdihydropyran and its use in the resolution of diols and the use of solid-supported reagents in the multi-step synthesis of epothilone B. Also covered is work towards tagged chiral induction reagents for solution-phase reactions with solid phase scavenger purification. |
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