The essential role of RNase H1 in the generation and clearance of RNA primers for mitochondrial DNA replication

An approach was made to enrich isolated mitochondrial replication intermediates (mtRIs) for intact RNA/DNA hybrids. The S9.6 antibody preferentially binds RNA/DNA hybrids over other nucleic acid substrates, and so it was applied to highly purified preparations of mtDNA. mtRIs bound by the antibody w...

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Bibliographic Details
Main Author: Holmes, J. B.
Published: University of Cambridge 2011
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604184

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