Investigation of the mechanisms underlying phenotype development and neurodegeneration in a transgenic mouse model of Huntington's disease
The R6/2 transgenic mouse model of HD displays a progressive neurological phenotype and motor and cognitive signs, comparable with signs and symptoms associated with HD. Experiments showed that R6/2 mice exhibited decreased response to dopaminergic locomotor stimulants with age. Chronic administrati...
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University of Cambridge
2001
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603995 |