Temporal control of translesion synthesis in vertebrates

Translesion synthesis is a potentially mutagenic method of damage encountered by replication forks in the DNA template. The high-fidelity replicative polymerase can be replaced by a translesion polymerase which is better able to accommodate damaged or mismatched bases in its active site. Mutation oc...

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Bibliographic Details
Main Author: Edmunds, C. E.
Published: University of Cambridge 2009
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598768