The Helicobacter pylori infection mediated regulatory T-cell response and in vivo supression of allergy and autoimmunity
Helicobacter pylori is a common human bacterial infection which usually causes asymptomatic gastritis, but 10-15% of individuals develop peptic ulcer disease (PUD) or gastric cancer. H. pylori stimulates a strong yet ineffective immune response in the gastric mucosa, which allows the infection to pe...
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University of Nottingham
2013
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598049 |
| Summary: | Helicobacter pylori is a common human bacterial infection which usually causes asymptomatic gastritis, but 10-15% of individuals develop peptic ulcer disease (PUD) or gastric cancer. H. pylori stimulates a strong yet ineffective immune response in the gastric mucosa, which allows the infection to persist for many decades. H. pylori modulates the host response to facilitate immune evasion via multiple mechanisms, however regulatory T cells (T regs) are thought to play an important role. Recent epidemiological studies have shown a reduced risk of allergy and autoimmune diseases amongst those with the infection. It was hypothesized that H. pylori-induced local T reg responses protect against PUD and pre-malignant pathology, whilst the systemic T reg response plays a role in suppressing allergy and autoimmunity. |
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