Assembly and inhibition of fibroblast growth factor signaling complexes

Two crystal structures of the ternary complex between FGF, FGFR and heparin (a functional and structural analogue of HS) have been determined, from which two models have been proposed; a symmetric model with 2:2:2 stoichiometry and an asymmetric model with 2:2:1 stoichiometry. It is not clear which...

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Bibliographic Details
Main Author: Brown, A.
Published: University of Cambridge 2010
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596958