The effect of engineered inter-domain CL-CHI disulphide bonds on IgG4 stability, functionality and fab arm exchange
The work presented here describes novel IgG4 formats that may be preferred format of choice when IgG4 is employed as a therapeutic. These formats have also improved our knowledge of IgG4 biology and may be used as tools to further investigate IgG4. IgG4 is one of four human IgG isotypes and has a nu...
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University of Kent
2012
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.592013 |