Analysis of telomere dynamics in human tissues
In Barrett's oesophagus, the metaplastic tissue displayed clonal growth characterised by very short homogeneous telomere profiles compared to the adjacent normal tissue. Short telomeres and fusions were also detected in normal dermis and melanocytic naevi with evidence of clonal telomere fusion...
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Cardiff University
2010
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ndltd-bl.uk-oai-ethos.bl.uk-5850522015-03-20T03:22:25ZAnalysis of telomere dynamics in human tissuesLetsolo, Boitelo Theresia2010In Barrett's oesophagus, the metaplastic tissue displayed clonal growth characterised by very short homogeneous telomere profiles compared to the adjacent normal tissue. Short telomeres and fusions were also detected in normal dermis and melanocytic naevi with evidence of clonal telomere fusion events. Such events can result in clonal expansion, which could confer selective advantage for other abnormalities that may derive neoplastic progression. These data are consistent with the view that telomere dysfunction in vivo may drive large-scale genomic instability of the type observed in early-stage neoplasia.616.994Cardiff Universityhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.585052http://orca.cf.ac.uk/55485/Electronic Thesis or Dissertation |
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616.994 |
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616.994 Letsolo, Boitelo Theresia Analysis of telomere dynamics in human tissues |
| description |
In Barrett's oesophagus, the metaplastic tissue displayed clonal growth characterised by very short homogeneous telomere profiles compared to the adjacent normal tissue. Short telomeres and fusions were also detected in normal dermis and melanocytic naevi with evidence of clonal telomere fusion events. Such events can result in clonal expansion, which could confer selective advantage for other abnormalities that may derive neoplastic progression. These data are consistent with the view that telomere dysfunction in vivo may drive large-scale genomic instability of the type observed in early-stage neoplasia. |
| author |
Letsolo, Boitelo Theresia |
| author_facet |
Letsolo, Boitelo Theresia |
| author_sort |
Letsolo, Boitelo Theresia |
| title |
Analysis of telomere dynamics in human tissues |
| title_short |
Analysis of telomere dynamics in human tissues |
| title_full |
Analysis of telomere dynamics in human tissues |
| title_fullStr |
Analysis of telomere dynamics in human tissues |
| title_full_unstemmed |
Analysis of telomere dynamics in human tissues |
| title_sort |
analysis of telomere dynamics in human tissues |
| publisher |
Cardiff University |
| publishDate |
2010 |
| url |
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.585052 |
| work_keys_str_mv |
AT letsoloboitelotheresia analysisoftelomeredynamicsinhumantissues |
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1716780489283469312 |