Analysis of telomere dynamics in human tissues
In Barrett's oesophagus, the metaplastic tissue displayed clonal growth characterised by very short homogeneous telomere profiles compared to the adjacent normal tissue. Short telomeres and fusions were also detected in normal dermis and melanocytic naevi with evidence of clonal telomere fusion...
| Main Author: | |
|---|---|
| Published: |
Cardiff University
2010
|
| Subjects: | |
| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.585052 |
| Summary: | In Barrett's oesophagus, the metaplastic tissue displayed clonal growth characterised by very short homogeneous telomere profiles compared to the adjacent normal tissue. Short telomeres and fusions were also detected in normal dermis and melanocytic naevi with evidence of clonal telomere fusion events. Such events can result in clonal expansion, which could confer selective advantage for other abnormalities that may derive neoplastic progression. These data are consistent with the view that telomere dysfunction in vivo may drive large-scale genomic instability of the type observed in early-stage neoplasia. |
|---|