Effect of cellular aging on fibroblastic phenotype and regulation by hyaluronan

Effect of cellular aging on fibroblastic phenotype and regulation by hyaluronan

Collectively, the data demonstrated that HA can serve as a signal integrator by facilitating TGF-beta11-mediated CD44-EGF-R-ERK interactions and ultimately regulate fibroblast phenotype. I propose a model to explain this novel mechanism and the functional consequence of age-dependent dysregulation....

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Main Author: Simpson, Russell Michael Lloyd
Published: Cardiff University 2010
Subjects:
612.7
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.585036
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spelling ndltd-bl.uk-oai-ethos.bl.uk-5850362015-03-20T03:22:57ZEffect of cellular aging on fibroblastic phenotype and regulation by hyaluronanSimpson, Russell Michael Lloyd2010Collectively, the data demonstrated that HA can serve as a signal integrator by facilitating TGF-beta11-mediated CD44-EGF-R-ERK interactions and ultimately regulate fibroblast phenotype. I propose a model to explain this novel mechanism and the functional consequence of age-dependent dysregulation. This mechanism may have direct implications for modifying the wound healing response, particularly for developing therapeutic strategies to improve healing in the elderly.612.7Cardiff Universityhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.585036http://orca.cf.ac.uk/55467/Electronic Thesis or Dissertation
collection NDLTD
sources NDLTD
topic 612.7
spellingShingle 612.7
Simpson, Russell Michael Lloyd
Effect of cellular aging on fibroblastic phenotype and regulation by hyaluronan
description Collectively, the data demonstrated that HA can serve as a signal integrator by facilitating TGF-beta11-mediated CD44-EGF-R-ERK interactions and ultimately regulate fibroblast phenotype. I propose a model to explain this novel mechanism and the functional consequence of age-dependent dysregulation. This mechanism may have direct implications for modifying the wound healing response, particularly for developing therapeutic strategies to improve healing in the elderly.
author Simpson, Russell Michael Lloyd
author_facet Simpson, Russell Michael Lloyd
author_sort Simpson, Russell Michael Lloyd
title Effect of cellular aging on fibroblastic phenotype and regulation by hyaluronan
title_short Effect of cellular aging on fibroblastic phenotype and regulation by hyaluronan
title_full Effect of cellular aging on fibroblastic phenotype and regulation by hyaluronan
title_fullStr Effect of cellular aging on fibroblastic phenotype and regulation by hyaluronan
title_full_unstemmed Effect of cellular aging on fibroblastic phenotype and regulation by hyaluronan
title_sort effect of cellular aging on fibroblastic phenotype and regulation by hyaluronan
publisher Cardiff University
publishDate 2010
url http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.585036
work_keys_str_mv AT simpsonrussellmichaellloyd effectofcellularagingonfibroblasticphenotypeandregulationbyhyaluronan
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