Proteoglycans in the corneal stroma and their role in development and pathology

Transmission electron microscopy of a human cornea with excess chondroitin sulphate/dermatan sulphate glycosaminoglycan showed that changes in proteoglycan structure, content and sulphation lead to the formation of abnormally large collagen fibrils. The lack of sulphation of keratin sulphate in MCD...

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Main Author:	Palka, Barbara Paulina
Published:	Cardiff University 2010
Subjects:	617.7
Online Access:	http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.584808

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spelling	ndltd-bl.uk-oai-ethos.bl.uk-5848082015-03-20T03:20:50ZProteoglycans in the corneal stroma and their role in development and pathologyPalka, Barbara Paulina2010Transmission electron microscopy of a human cornea with excess chondroitin sulphate/dermatan sulphate glycosaminoglycan showed that changes in proteoglycan structure, content and sulphation lead to the formation of abnormally large collagen fibrils. The lack of sulphation of keratin sulphate in MCD also led to abnormally large fibrils, which are present in the deep stromal layers. These findings suggest overlapping roles of the two proteoglycan populations in the corneal stroma with possible feedback mechanisms, too. Taken together, the findings of this thesis indicate the central role played by proteoglycan-collagen interactions in the development and maintenance of properly formed corneal stroma.617.7Cardiff Universityhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.584808http://orca.cf.ac.uk/54160/Electronic Thesis or Dissertation
collection	NDLTD
sources	NDLTD
topic	617.7
spellingShingle	617.7 Palka, Barbara Paulina Proteoglycans in the corneal stroma and their role in development and pathology
description	Transmission electron microscopy of a human cornea with excess chondroitin sulphate/dermatan sulphate glycosaminoglycan showed that changes in proteoglycan structure, content and sulphation lead to the formation of abnormally large collagen fibrils. The lack of sulphation of keratin sulphate in MCD also led to abnormally large fibrils, which are present in the deep stromal layers. These findings suggest overlapping roles of the two proteoglycan populations in the corneal stroma with possible feedback mechanisms, too. Taken together, the findings of this thesis indicate the central role played by proteoglycan-collagen interactions in the development and maintenance of properly formed corneal stroma.
author	Palka, Barbara Paulina
author_facet	Palka, Barbara Paulina
author_sort	Palka, Barbara Paulina
title	Proteoglycans in the corneal stroma and their role in development and pathology
title_short	Proteoglycans in the corneal stroma and their role in development and pathology
title_full	Proteoglycans in the corneal stroma and their role in development and pathology
title_fullStr	Proteoglycans in the corneal stroma and their role in development and pathology
title_full_unstemmed	Proteoglycans in the corneal stroma and their role in development and pathology
title_sort	proteoglycans in the corneal stroma and their role in development and pathology
publisher	Cardiff University
publishDate	2010
url	http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.584808
work_keys_str_mv	AT palkabarbarapaulina proteoglycansinthecornealstromaandtheirroleindevelopmentandpathology
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Proteoglycans in the corneal stroma and their role in development and pathology

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