The synthesis of group 9 complexes for use as transfer hydrogenation catalysts and anti-cancer agents

• Main Author: Lucas, Stephanie Jayne
• Published: University of Leeds 2013
• Subjects: 547
• Online Access: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.581646

This thesis concerns the synthesis of group 9 Cp* and hydroxyl tethered Cp* based complexes for their use as both anti-cancer agents and transfer hydrogenation catalysts. The successful catalysts were immobilised covalently onto Wang resin for their use as recyclable transfer hydrogenation catalysts in the reduction of benzaldehyde and acetophenone. Chapter 1 is a current review of transfer hydrogenation using metal-arene complexes and immobilised catalysts. Chapter 2 describes the synthesis and characterisation of group 9 hydroxyl tethered Cp* based dihalide dimers. Chapter 3 describes the synthesis and characterisation of group 9 Cp* and hydroxyl tethered Cp* based pyridine dihalide complexes. Chapter 4 describes the syntheseis and characterisation of group 9 Cp* and hydroxyl tethered Cp* based picolinamide halide complexes. Chapter 5 describes the synthesis and characterisation of iridium Cp* chloride bidentate complexes, where the bidentate ligand is either an XL or 2L ligand. Chapter 6 describes the catalytic testing of compounds discussed in Chapters 2-5 for the reduction of benzaldehyde and acetophenone. Chapter 7 describes the synthesis and characterisation and catalytic activity of immobilised group 9 hydroxyl tethered Cp* based dichloride dimers. Chapter 8 describes in vitro IC50 results for select compounds described in Chapters 2-5 against a range of cancer cell lines. Chapter 9 gives experimental details for processes discussed in Chapters 2-8 and characterisation data for the novel compounds discussed in Chapters 2-5.