Modulation of myocardium repair after ischemic injury : role of macrophages

Macrophages are primary responders that are involved in regulation of left ventricular remodeling post myocardial infarct (MI) at various levels. Macrophage role post ischemia can be best studied by eliminating or blocking their population and also by increasing their numbers, and determining the ou...

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Main Author: Mohammed, Salman Afroze Azmi
Published: Open University 2012
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.580134
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spelling ndltd-bl.uk-oai-ethos.bl.uk-5801342015-03-20T05:39:23ZModulation of myocardium repair after ischemic injury : role of macrophagesMohammed, Salman Afroze Azmi2012Macrophages are primary responders that are involved in regulation of left ventricular remodeling post myocardial infarct (MI) at various levels. Macrophage role post ischemia can be best studied by eliminating or blocking their population and also by increasing their numbers, and determining the outcome. Four different approaches to modulate macrophage number or activity have been used: a) human diphtheria toxin receptor (hDTR) transgenic mice; b) injection with clodronate liposomes (CL) in C57 mice; c) pharmacologic blockade of TLR4 which is expressed also in macrophages; d) selection of Ml or inflammatory macrophages, by adoptive transfer of NF-kB P50-/- bone marrow (BM).616.1237Open Universityhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.580134Electronic Thesis or Dissertation
collection NDLTD
sources NDLTD
topic 616.1237
spellingShingle 616.1237
Mohammed, Salman Afroze Azmi
Modulation of myocardium repair after ischemic injury : role of macrophages
description Macrophages are primary responders that are involved in regulation of left ventricular remodeling post myocardial infarct (MI) at various levels. Macrophage role post ischemia can be best studied by eliminating or blocking their population and also by increasing their numbers, and determining the outcome. Four different approaches to modulate macrophage number or activity have been used: a) human diphtheria toxin receptor (hDTR) transgenic mice; b) injection with clodronate liposomes (CL) in C57 mice; c) pharmacologic blockade of TLR4 which is expressed also in macrophages; d) selection of Ml or inflammatory macrophages, by adoptive transfer of NF-kB P50-/- bone marrow (BM).
author Mohammed, Salman Afroze Azmi
author_facet Mohammed, Salman Afroze Azmi
author_sort Mohammed, Salman Afroze Azmi
title Modulation of myocardium repair after ischemic injury : role of macrophages
title_short Modulation of myocardium repair after ischemic injury : role of macrophages
title_full Modulation of myocardium repair after ischemic injury : role of macrophages
title_fullStr Modulation of myocardium repair after ischemic injury : role of macrophages
title_full_unstemmed Modulation of myocardium repair after ischemic injury : role of macrophages
title_sort modulation of myocardium repair after ischemic injury : role of macrophages
publisher Open University
publishDate 2012
url http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.580134
work_keys_str_mv AT mohammedsalmanafrozeazmi modulationofmyocardiumrepairafterischemicinjuryroleofmacrophages
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