Modulation of myocardium repair after ischemic injury : role of macrophages
Macrophages are primary responders that are involved in regulation of left ventricular remodeling post myocardial infarct (MI) at various levels. Macrophage role post ischemia can be best studied by eliminating or blocking their population and also by increasing their numbers, and determining the ou...
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ndltd-bl.uk-oai-ethos.bl.uk-5801342015-03-20T05:39:23ZModulation of myocardium repair after ischemic injury : role of macrophagesMohammed, Salman Afroze Azmi2012Macrophages are primary responders that are involved in regulation of left ventricular remodeling post myocardial infarct (MI) at various levels. Macrophage role post ischemia can be best studied by eliminating or blocking their population and also by increasing their numbers, and determining the outcome. Four different approaches to modulate macrophage number or activity have been used: a) human diphtheria toxin receptor (hDTR) transgenic mice; b) injection with clodronate liposomes (CL) in C57 mice; c) pharmacologic blockade of TLR4 which is expressed also in macrophages; d) selection of Ml or inflammatory macrophages, by adoptive transfer of NF-kB P50-/- bone marrow (BM).616.1237Open Universityhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.580134Electronic Thesis or Dissertation |
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616.1237 Mohammed, Salman Afroze Azmi Modulation of myocardium repair after ischemic injury : role of macrophages |
description |
Macrophages are primary responders that are involved in regulation of left ventricular remodeling post myocardial infarct (MI) at various levels. Macrophage role post ischemia can be best studied by eliminating or blocking their population and also by increasing their numbers, and determining the outcome. Four different approaches to modulate macrophage number or activity have been used: a) human diphtheria toxin receptor (hDTR) transgenic mice; b) injection with clodronate liposomes (CL) in C57 mice; c) pharmacologic blockade of TLR4 which is expressed also in macrophages; d) selection of Ml or inflammatory macrophages, by adoptive transfer of NF-kB P50-/- bone marrow (BM). |
author |
Mohammed, Salman Afroze Azmi |
author_facet |
Mohammed, Salman Afroze Azmi |
author_sort |
Mohammed, Salman Afroze Azmi |
title |
Modulation of myocardium repair after ischemic injury : role of macrophages |
title_short |
Modulation of myocardium repair after ischemic injury : role of macrophages |
title_full |
Modulation of myocardium repair after ischemic injury : role of macrophages |
title_fullStr |
Modulation of myocardium repair after ischemic injury : role of macrophages |
title_full_unstemmed |
Modulation of myocardium repair after ischemic injury : role of macrophages |
title_sort |
modulation of myocardium repair after ischemic injury : role of macrophages |
publisher |
Open University |
publishDate |
2012 |
url |
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.580134 |
work_keys_str_mv |
AT mohammedsalmanafrozeazmi modulationofmyocardiumrepairafterischemicinjuryroleofmacrophages |
_version_ |
1716794017229832192 |