Investigating a co-operative link between TGF-β and Lyn kinase in Chronic Myeloid Leukaemia

Chronic myeloid leukaemia (CML) is a myeloproliferative disorder characterised by uncontrolled proliferation of haematopoietic cells driven by the fusion gene Bcr-Abl. The advent of a mechanism specific kinase inhibitor, Imatinib, targeting the constitutively active Bcr-Abl kinase has paved the way...

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Bibliographic Details
Main Author: Smith, Paul
Published: University of East Anglia 2011
Subjects:
570
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.569372