FOXP3 regulates metastatic spread of breast cancer via control of expression of CXCR4 chemokine receptor
The FOXP3 transcription factor can regulate T cell migration by inhibiting expression of CXCR4, the receptor for the chemokine CXCL12. The increased expression of CXCR4 by breast cancer cells can drive metastatic migration towards sites that express CXCL12. Intracellular trafficking of FOXP3 to the...
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University of Newcastle Upon Tyne
2012
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.567019 |