Design, synthesis and evaluation of inhibitors against tumour-associated protease

Proteases are a class of physiologically active proteins which lead different biochemistry reactions and are responsible to many physiology and pathology processes. Protease inhibitors therefore have emerged as potent therapeutic agents for various diseases. Successful examples include Cathepsin inh...

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Main Author:	Hu, X.
Published:	Queen's University Belfast 2012
Subjects:	616.994
Online Access:	http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.557630

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spelling	ndltd-bl.uk-oai-ethos.bl.uk-5576302015-03-20T04:52:50ZDesign, synthesis and evaluation of inhibitors against tumour-associated proteaseHu, X.2012Proteases are a class of physiologically active proteins which lead different biochemistry reactions and are responsible to many physiology and pathology processes. Protease inhibitors therefore have emerged as potent therapeutic agents for various diseases. Successful examples include Cathepsin inhibitors and HIV aspartste protease inhibitors, while the matrix metalloproteinase inhibitors are deemed to be failure examples. In this thesis, a series of inhibitors of two distinct proteases seprase and proteasome were designed, synthesized and evaluated through different methods. The assessment of methodologies and clinical applications was also provided in guiding the future works.616.994Queen's University Belfasthttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.557630Electronic Thesis or Dissertation
collection	NDLTD
sources	NDLTD
topic	616.994
spellingShingle	616.994 Hu, X. Design, synthesis and evaluation of inhibitors against tumour-associated protease
description	Proteases are a class of physiologically active proteins which lead different biochemistry reactions and are responsible to many physiology and pathology processes. Protease inhibitors therefore have emerged as potent therapeutic agents for various diseases. Successful examples include Cathepsin inhibitors and HIV aspartste protease inhibitors, while the matrix metalloproteinase inhibitors are deemed to be failure examples. In this thesis, a series of inhibitors of two distinct proteases seprase and proteasome were designed, synthesized and evaluated through different methods. The assessment of methodologies and clinical applications was also provided in guiding the future works.
author	Hu, X.
author_facet	Hu, X.
author_sort	Hu, X.
title	Design, synthesis and evaluation of inhibitors against tumour-associated protease
title_short	Design, synthesis and evaluation of inhibitors against tumour-associated protease
title_full	Design, synthesis and evaluation of inhibitors against tumour-associated protease
title_fullStr	Design, synthesis and evaluation of inhibitors against tumour-associated protease
title_full_unstemmed	Design, synthesis and evaluation of inhibitors against tumour-associated protease
title_sort	design, synthesis and evaluation of inhibitors against tumour-associated protease
publisher	Queen's University Belfast
publishDate	2012
url	http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.557630
work_keys_str_mv	AT hux designsynthesisandevaluationofinhibitorsagainsttumourassociatedprotease
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Design, synthesis and evaluation of inhibitors against tumour-associated protease

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