Cross-regulation of prosaposin and sphingosine kinase signalling in prostate cancer
Sphingosine kinase 1 (SPHK1) is an oncogenic enzyme that is upregulated in a wide range of human tumours and is associated with cancer progression. The product of SPHK1's activity, sphingosine-1-phosphate (S1P) enhances metastatic potential by promoting cancer cell migration and invasion. Our g...
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Imperial College London
2012
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.550239 |