Synthesis of sulforaphane and inhibition of cytochrome P450 enzymes as a basis for antigenotoxicity

Sulforaphane was synthesised with an overall yield of 15%, essentially via 1-methylsulfinylphthalimidobutane, which was oxidised to the sulfoxide moiety. Sulforaphane was a competitive inhibitor of CYPO2E1 in acetone-induced Sprague-Dawley rat microsomes (Ki 37.9 4.5 M), as measured by the p-nitroph...

Full description

Bibliographic Details
Main Author: Barcelo Batllori, Silvia Barcelo
Published: Aston University 1997
Subjects:
572
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.544624

Similar Items