Modelling saposin deficiency in Drosophila : progressive neurodegeneration, storage and physiological decline
Saposin deficiency is a lysosomal storage disorder (LSD) characterised by the lysosomal accumulation of sphingolipids. The disorder is caused by mutations in the prosaposin gene, which encodes 4 activator proteins: saposins A - D. Mutations affecting individual saposins lead to different LSDs. There...
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University of York
2010
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.535040 |