The effects of acidosis, glutamine starvation and inhibition of the pH sensitive SNAT 2 amino acid transporter on protein metabolism in L6 muscle cells
Uraemia in end-stage renal disease patients leads to wasting of lean tissue, partly through the effects of acidosis that induce negative protein balance. Insulin resistance in these patients is also a major cause of muscle wasting, suggesting that low pH has a significant effect on insulin signallin...
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University of Leicester
2009
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.530563 |