Molecular analysis of claspin function in vertebrate cells
Claspin is a large, acidic, DNA binding protein required for the ATR mediated activation of Chk1 in response to DNA replication stress. Upon checkpoint activation Claspin is phosphorylated which allows binding to Chk1. This binding in turn promotes the phosphorylation and activation of Chk1 by ATR....
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University of Glasgow
2010
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.512092 |