Incorporation of 3-s-phosphorothiolates into oligonucleotides : changing direction for RNA interference
The main focus of this work falls into two sections. Firstly the synthesis and hybridisation studies of RNA duplexes containing 3'-S-phosphorothiolate (3'-sp) linkages, which are prepared using traditional automated 3'-5' solid-phase phosphoramidite chemistry. Secondly, investiga...
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University of Liverpool
2008
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.507190 |