TIMP-3 interaction with aggrecanase 1 (ADAMTS-4) and aggrecanse 2 (ADAMTS-5)investigated by site-directed mutagenesis
Degradation of the proteoglycan aggrecan, one ofthe major components ofthe cartilage matrix, is thought to be a critical step in the development of osteoarthritis (OA). Both matrix metalloproteinases (MMPs) and aggrecanases [members of the ADAMTS (a disintegrin and metalloprotease with thrombospondi...
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Imperial College London
2008
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506803 |