Developing viral tools and regulatable gene expression systems to study the dynamics of polyglutamine disease inclusions
Co-chaperone proteins are important mediators of protein triage, deciding whether misfolded proteins should be degraded or refolded. The accumulation of misfolded proteins is thought to be a major contributing factor to polyglutamine diseases, where the expansion of a polyglutamine tract in the dise...
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University of Bristol
2009
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.505763 |