Developing viral tools and regulatable gene expression systems to study the dynamics of polyglutamine disease inclusions
Co-chaperone proteins are important mediators of protein triage, deciding whether misfolded proteins should be degraded or refolded. The accumulation of misfolded proteins is thought to be a major contributing factor to polyglutamine diseases, where the expansion of a polyglutamine tract in the dise...
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ndltd-bl.uk-oai-ethos.bl.uk-5057632015-03-20T05:44:30ZDeveloping viral tools and regulatable gene expression systems to study the dynamics of polyglutamine disease inclusionsHickman, Matthew Richard2009Co-chaperone proteins are important mediators of protein triage, deciding whether misfolded proteins should be degraded or refolded. The accumulation of misfolded proteins is thought to be a major contributing factor to polyglutamine diseases, where the expansion of a polyglutamine tract in the disease protein leads to a conformational change in the protein's structure. A major consequence of this misfolding is the formation of intracellular inclusions, which are thought to play an important role in disease pathogenesis.616.8University of Bristolhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.505763Electronic Thesis or Dissertation |
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616.8 Hickman, Matthew Richard Developing viral tools and regulatable gene expression systems to study the dynamics of polyglutamine disease inclusions |
description |
Co-chaperone proteins are important mediators of protein triage, deciding whether misfolded proteins should be degraded or refolded. The accumulation of misfolded proteins is thought to be a major contributing factor to polyglutamine diseases, where the expansion of a polyglutamine tract in the disease protein leads to a conformational change in the protein's structure. A major consequence of this misfolding is the formation of intracellular inclusions, which are thought to play an important role in disease pathogenesis. |
author |
Hickman, Matthew Richard |
author_facet |
Hickman, Matthew Richard |
author_sort |
Hickman, Matthew Richard |
title |
Developing viral tools and regulatable gene expression systems to study the dynamics of polyglutamine disease inclusions |
title_short |
Developing viral tools and regulatable gene expression systems to study the dynamics of polyglutamine disease inclusions |
title_full |
Developing viral tools and regulatable gene expression systems to study the dynamics of polyglutamine disease inclusions |
title_fullStr |
Developing viral tools and regulatable gene expression systems to study the dynamics of polyglutamine disease inclusions |
title_full_unstemmed |
Developing viral tools and regulatable gene expression systems to study the dynamics of polyglutamine disease inclusions |
title_sort |
developing viral tools and regulatable gene expression systems to study the dynamics of polyglutamine disease inclusions |
publisher |
University of Bristol |
publishDate |
2009 |
url |
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.505763 |
work_keys_str_mv |
AT hickmanmatthewrichard developingviraltoolsandregulatablegeneexpressionsystemstostudythedynamicsofpolyglutaminediseaseinclusions |
_version_ |
1716793643410391040 |