Developing viral tools and regulatable gene expression systems to study the dynamics of polyglutamine disease inclusions

Co-chaperone proteins are important mediators of protein triage, deciding whether misfolded proteins should be degraded or refolded. The accumulation of misfolded proteins is thought to be a major contributing factor to polyglutamine diseases, where the expansion of a polyglutamine tract in the dise...

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Main Author: Hickman, Matthew Richard
Published: University of Bristol 2009
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.505763
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spelling ndltd-bl.uk-oai-ethos.bl.uk-5057632015-03-20T05:44:30ZDeveloping viral tools and regulatable gene expression systems to study the dynamics of polyglutamine disease inclusionsHickman, Matthew Richard2009Co-chaperone proteins are important mediators of protein triage, deciding whether misfolded proteins should be degraded or refolded. The accumulation of misfolded proteins is thought to be a major contributing factor to polyglutamine diseases, where the expansion of a polyglutamine tract in the disease protein leads to a conformational change in the protein's structure. A major consequence of this misfolding is the formation of intracellular inclusions, which are thought to play an important role in disease pathogenesis.616.8University of Bristolhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.505763Electronic Thesis or Dissertation
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sources NDLTD
topic 616.8
spellingShingle 616.8
Hickman, Matthew Richard
Developing viral tools and regulatable gene expression systems to study the dynamics of polyglutamine disease inclusions
description Co-chaperone proteins are important mediators of protein triage, deciding whether misfolded proteins should be degraded or refolded. The accumulation of misfolded proteins is thought to be a major contributing factor to polyglutamine diseases, where the expansion of a polyglutamine tract in the disease protein leads to a conformational change in the protein's structure. A major consequence of this misfolding is the formation of intracellular inclusions, which are thought to play an important role in disease pathogenesis.
author Hickman, Matthew Richard
author_facet Hickman, Matthew Richard
author_sort Hickman, Matthew Richard
title Developing viral tools and regulatable gene expression systems to study the dynamics of polyglutamine disease inclusions
title_short Developing viral tools and regulatable gene expression systems to study the dynamics of polyglutamine disease inclusions
title_full Developing viral tools and regulatable gene expression systems to study the dynamics of polyglutamine disease inclusions
title_fullStr Developing viral tools and regulatable gene expression systems to study the dynamics of polyglutamine disease inclusions
title_full_unstemmed Developing viral tools and regulatable gene expression systems to study the dynamics of polyglutamine disease inclusions
title_sort developing viral tools and regulatable gene expression systems to study the dynamics of polyglutamine disease inclusions
publisher University of Bristol
publishDate 2009
url http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.505763
work_keys_str_mv AT hickmanmatthewrichard developingviraltoolsandregulatablegeneexpressionsystemstostudythedynamicsofpolyglutaminediseaseinclusions
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