Identification of the gene involved in holomycin production and gene sequencing of stremptomyces cluvuligerus
Holomycin is a poor antibiotic (Oliva et al, 2001) that is made in reasonable quantities by S. clavuligerus - which is better known for production of clavulanic acid, a component of the successful clinical drug, Augmentin. Holomycin is a wasteful metabolite in the context of commercial clavulanic ac...
| Main Author: | |
|---|---|
| Published: |
University of Strathclyde
2009
|
| Subjects: | |
| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502279 |
| Summary: | Holomycin is a poor antibiotic (Oliva et al, 2001) that is made in reasonable quantities by S. clavuligerus - which is better known for production of clavulanic acid, a component of the successful clinical drug, Augmentin. Holomycin is a wasteful metabolite in the context of commercial clavulanic acid production, and mutants that no longer make holomycin have increased clavulanic acid productivity, Likewise, mutants that no longer make clavulanic acid will over-produce holomycin (de la Fuente et al, 2002). The biosynthesis of holomycin has not been studied. |
|---|