| Summary: | Based on ethnobotanical information collected from personally speaking to traditional herbalists in some communities in Nigeria. medicinal plants used in the treatment of diabetes mellitus were collected. Twelve of them were evaluated for acute and sub-chronic hypoglycaemic activity in normal mice following oral administration. These included 75% methanolic extracts of Alchornea cordifolia. Anthocleista vogelii. Cassia nigricans, Cassia sieberiana, Detarium microcarpum, Mitragyna inermis, Nauclea latifolia, Parinaripolyandra, Picralima nitida, Prosopis africana, Pseudocedrela kotschyii and Strychnos spinosa. None of the extracts produced a statistically significant reduction in serum glucose in normal mice after 2 hours. However, four of the extracts (D. microcarpum, P. africana, P. nitida and P. polyandra) produced significant reductions in blood glucose concentrations within weeks; they also produced weight loss or weight stasis.
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