| Summary: | Calibrated funclional magnetic resonance (MRl) has received growing interest in recent years, becoming recognized as a viable technique for quantitatively examining both the cerebral blood flow (CBF) and oxygen metabolism (CMRO2) changes associated with neural activation. It offers a relatively novel approach for examining the physiological effects of ageing and disease in the brain, which if measured by the blood oxygen level dependent (BOLD) signal alone, may be difficult to interpret, Traditionally, a hypercania calibration technique involving the inhalation of a carbon dioxide gas mkture during arterial spin labellmg (ASL) MRI scanning has seentlie method of choice. However, other techniques such as breath-hold induced hypercapnia, and the comparatively new hyperoxia calibration technique involving the inhalation of high concentration oxygen gas, have also been explored as viable alternatives.
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