Sequence, structure and functional studies of viper venom proteolytic enzymes
Snake venom proteins are potential sources for novel drug design both for treatment of snake bites and for human genetic disorders. To achieve these, the basic sequence, structure and functional relationships of venom proteins should be understood. Proteolytic enzymes such as metallo and serine prot...
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University of Reading
2008
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ndltd-bl.uk-oai-ethos.bl.uk-5013212016-06-21T03:32:06ZSequence, structure and functional studies of viper venom proteolytic enzymesVaiyapuri, Sakthivel2008Snake venom proteins are potential sources for novel drug design both for treatment of snake bites and for human genetic disorders. To achieve these, the basic sequence, structure and functional relationships of venom proteins should be understood. Proteolytic enzymes such as metallo and serine proteases are the major components of venom in vipers and are responsible for local and systematic envenomation effects. We have purified, partially sequenced and functionally characterised a serine protease, rhinocerase from the venom of Bitis gabonica rhinoceros. Rhinocerase is a multifunctional enzyme with kininogenase, clotting and defibrase activities.615.942University of Readinghttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501321Electronic Thesis or Dissertation |
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615.942 Vaiyapuri, Sakthivel Sequence, structure and functional studies of viper venom proteolytic enzymes |
| description |
Snake venom proteins are potential sources for novel drug design both for treatment of snake bites and for human genetic disorders. To achieve these, the basic sequence, structure and functional relationships of venom proteins should be understood. Proteolytic enzymes such as metallo and serine proteases are the major components of venom in vipers and are responsible for local and systematic envenomation effects. We have purified, partially sequenced and functionally characterised a serine protease, rhinocerase from the venom of Bitis gabonica rhinoceros. Rhinocerase is a multifunctional enzyme with kininogenase, clotting and defibrase activities. |
| author |
Vaiyapuri, Sakthivel |
| author_facet |
Vaiyapuri, Sakthivel |
| author_sort |
Vaiyapuri, Sakthivel |
| title |
Sequence, structure and functional studies of viper venom proteolytic enzymes |
| title_short |
Sequence, structure and functional studies of viper venom proteolytic enzymes |
| title_full |
Sequence, structure and functional studies of viper venom proteolytic enzymes |
| title_fullStr |
Sequence, structure and functional studies of viper venom proteolytic enzymes |
| title_full_unstemmed |
Sequence, structure and functional studies of viper venom proteolytic enzymes |
| title_sort |
sequence, structure and functional studies of viper venom proteolytic enzymes |
| publisher |
University of Reading |
| publishDate |
2008 |
| url |
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501321 |
| work_keys_str_mv |
AT vaiyapurisakthivel sequencestructureandfunctionalstudiesofvipervenomproteolyticenzymes |
| _version_ |
1718313173356904448 |