Effect of sulforaphane on neurotransmitter receptors : an insight into the regulatory networks for chemoprevention studies

Effect of sulforaphane on neurotransmitter receptors : an insight into the regulatory networks for chemoprevention studies

Sulforaphane is a potent phase II enzyme inducer and well-known dietary chemopreventive agent. A proteomic study on colon adenocarcinoma Caco-2 cells was performed to detect differentially-expressed proteins following exposure to sulforaphane. Results showed that sulforaphane down-regulated the expr...

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Main Author: Mastrangelo, Lina
Published: University of East Anglia 2009
Subjects:
616.99405
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501107
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spelling ndltd-bl.uk-oai-ethos.bl.uk-5011072015-03-20T04:56:07ZEffect of sulforaphane on neurotransmitter receptors : an insight into the regulatory networks for chemoprevention studiesMastrangelo, Lina2009Sulforaphane is a potent phase II enzyme inducer and well-known dietary chemopreventive agent. A proteomic study on colon adenocarcinoma Caco-2 cells was performed to detect differentially-expressed proteins following exposure to sulforaphane. Results showed that sulforaphane down-regulated the expression of serotonin receptors, decreased serotonin reuptake transporter (SERT) and upregulated nicotinic acetylcholine receptors (nAChRs), promoting signals for serotonin release. The neurotransmitter serotonin induces cellular responses by mediating G-proteins, and activating specific receptors which are important in the proliferation of colon cancer cells. These observed effects of sulforaphane on neurotransmitter receptors in Caco-2 cells may provide new insights into developing cancer prevention strategies through diet.616.99405University of East Angliahttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501107Electronic Thesis or Dissertation
collection NDLTD
sources NDLTD
topic 616.99405
spellingShingle 616.99405
Mastrangelo, Lina
Effect of sulforaphane on neurotransmitter receptors : an insight into the regulatory networks for chemoprevention studies
description Sulforaphane is a potent phase II enzyme inducer and well-known dietary chemopreventive agent. A proteomic study on colon adenocarcinoma Caco-2 cells was performed to detect differentially-expressed proteins following exposure to sulforaphane. Results showed that sulforaphane down-regulated the expression of serotonin receptors, decreased serotonin reuptake transporter (SERT) and upregulated nicotinic acetylcholine receptors (nAChRs), promoting signals for serotonin release. The neurotransmitter serotonin induces cellular responses by mediating G-proteins, and activating specific receptors which are important in the proliferation of colon cancer cells. These observed effects of sulforaphane on neurotransmitter receptors in Caco-2 cells may provide new insights into developing cancer prevention strategies through diet.
author Mastrangelo, Lina
author_facet Mastrangelo, Lina
author_sort Mastrangelo, Lina
title Effect of sulforaphane on neurotransmitter receptors : an insight into the regulatory networks for chemoprevention studies
title_short Effect of sulforaphane on neurotransmitter receptors : an insight into the regulatory networks for chemoprevention studies
title_full Effect of sulforaphane on neurotransmitter receptors : an insight into the regulatory networks for chemoprevention studies
title_fullStr Effect of sulforaphane on neurotransmitter receptors : an insight into the regulatory networks for chemoprevention studies
title_full_unstemmed Effect of sulforaphane on neurotransmitter receptors : an insight into the regulatory networks for chemoprevention studies
title_sort effect of sulforaphane on neurotransmitter receptors : an insight into the regulatory networks for chemoprevention studies
publisher University of East Anglia
publishDate 2009
url http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501107
work_keys_str_mv AT mastrangelolina effectofsulforaphaneonneurotransmitterreceptorsaninsightintotheregulatorynetworksforchemopreventionstudies
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