Presynaptic kainate receptors and the regulation of thalamocotical transmission in developing barrel cortex

Presynaptic kainate receptors and the regulation of thalamocotical transmission in developing barrel cortex

Kainatc receptors (K Rs) arc members of the ionotroplc glutamatc receptor family and are tetramers made up of combinations of GluR5, 6 & 7 and KAI & 2 subunits. KARs arc highly expressed in the brain where they are located both pre- and postsynaptically and regulate network function. Recent...

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Main Author: Jouhanneau, Jean-Sebastien
Published: University of Bristol 2008
Subjects:
612.015756
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500453
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spelling ndltd-bl.uk-oai-ethos.bl.uk-5004532015-03-20T05:45:18ZPresynaptic kainate receptors and the regulation of thalamocotical transmission in developing barrel cortexJouhanneau, Jean-Sebastien2008Kainatc receptors (K Rs) arc members of the ionotroplc glutamatc receptor family and are tetramers made up of combinations of GluR5, 6 & 7 and KAI & 2 subunits. KARs arc highly expressed in the brain where they are located both pre- and postsynaptically and regulate network function. Recent work has shown that KARs function was closely related to their subunit composition, This is best described in hippocampus where KARs regulate circuit excitability and where GIuR6 subunit has been implicated in mediating temporal lobe epilepsy. KARs are also highly expressed early in development in sensory pathways and have been shown to be involved in regulating short-term synaptic plasticity during development; however little is known about their subunit specific roles in this mechanism.612.015756University of Bristolhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500453Electronic Thesis or Dissertation
collection NDLTD
sources NDLTD
topic 612.015756
spellingShingle 612.015756
Jouhanneau, Jean-Sebastien
Presynaptic kainate receptors and the regulation of thalamocotical transmission in developing barrel cortex
description Kainatc receptors (K Rs) arc members of the ionotroplc glutamatc receptor family and are tetramers made up of combinations of GluR5, 6 & 7 and KAI & 2 subunits. KARs arc highly expressed in the brain where they are located both pre- and postsynaptically and regulate network function. Recent work has shown that KARs function was closely related to their subunit composition, This is best described in hippocampus where KARs regulate circuit excitability and where GIuR6 subunit has been implicated in mediating temporal lobe epilepsy. KARs are also highly expressed early in development in sensory pathways and have been shown to be involved in regulating short-term synaptic plasticity during development; however little is known about their subunit specific roles in this mechanism.
author Jouhanneau, Jean-Sebastien
author_facet Jouhanneau, Jean-Sebastien
author_sort Jouhanneau, Jean-Sebastien
title Presynaptic kainate receptors and the regulation of thalamocotical transmission in developing barrel cortex
title_short Presynaptic kainate receptors and the regulation of thalamocotical transmission in developing barrel cortex
title_full Presynaptic kainate receptors and the regulation of thalamocotical transmission in developing barrel cortex
title_fullStr Presynaptic kainate receptors and the regulation of thalamocotical transmission in developing barrel cortex
title_full_unstemmed Presynaptic kainate receptors and the regulation of thalamocotical transmission in developing barrel cortex
title_sort presynaptic kainate receptors and the regulation of thalamocotical transmission in developing barrel cortex
publisher University of Bristol
publishDate 2008
url http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500453
work_keys_str_mv AT jouhanneaujeansebastien presynaptickainatereceptorsandtheregulationofthalamocoticaltransmissionindevelopingbarrelcortex
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