Investigation on the role of lipids in the regulation of protein function
Type 11 amphiphiles have been shown in vitro to activate the catalytic activity of ate-determining enzyme of lipid metabolism CTP: phosphocholine cytidylyltransferase (CCT). Membrane stored curvature elastic stress has been suggested as a regulator of CCT activity. It has been postulated that Type I...
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University of Southampton
2008
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.496089 |
| Summary: | Type 11 amphiphiles have been shown in vitro to activate the catalytic activity of ate-determining enzyme of lipid metabolism CTP: phosphocholine cytidylyltransferase (CCT). Membrane stored curvature elastic stress has been suggested as a regulator of CCT activity. It has been postulated that Type II lipids, which form membranes with high curvature elastic stress, activate CCT by increasing the partitioning of CCT onto the membrane. Conversely, Type I lipids inhibit CCT activity by decreaskig stored elastic energy. |
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