Molecular interactions of pyrethroid insecticides with insect ion channels

Much of the present knowledge of the activity of pyrethroids on the insect Na⁺ channel has come from the electrophysiological investigation of Na⁺ channels expressed heterologously in the Xenopus laevis oocyte expression system. The effects of the naturally occurring pyrethroid resistance mutations,...

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Main Author: Verdin, Paul Stephen
Published: University of Nottingham 2008
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Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.495529
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spelling ndltd-bl.uk-oai-ethos.bl.uk-4955292015-03-20T04:57:29ZMolecular interactions of pyrethroid insecticides with insect ion channelsVerdin, Paul Stephen2008Much of the present knowledge of the activity of pyrethroids on the insect Na⁺ channel has come from the electrophysiological investigation of Na⁺ channels expressed heterologously in the Xenopus laevis oocyte expression system. The effects of the naturally occurring pyrethroid resistance mutations, located within the Na⁺ channel gene(s), have also been studied in this way. These studies have yielded a wealth of information, but make several assumptions - that insect Na⁺ channels behave normally in this alien environment and that the expressed channels accurately represent the range channels present in neurons.632.9517University of Nottinghamhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.495529Electronic Thesis or Dissertation
collection NDLTD
sources NDLTD
topic 632.9517
spellingShingle 632.9517
Verdin, Paul Stephen
Molecular interactions of pyrethroid insecticides with insect ion channels
description Much of the present knowledge of the activity of pyrethroids on the insect Na⁺ channel has come from the electrophysiological investigation of Na⁺ channels expressed heterologously in the Xenopus laevis oocyte expression system. The effects of the naturally occurring pyrethroid resistance mutations, located within the Na⁺ channel gene(s), have also been studied in this way. These studies have yielded a wealth of information, but make several assumptions - that insect Na⁺ channels behave normally in this alien environment and that the expressed channels accurately represent the range channels present in neurons.
author Verdin, Paul Stephen
author_facet Verdin, Paul Stephen
author_sort Verdin, Paul Stephen
title Molecular interactions of pyrethroid insecticides with insect ion channels
title_short Molecular interactions of pyrethroid insecticides with insect ion channels
title_full Molecular interactions of pyrethroid insecticides with insect ion channels
title_fullStr Molecular interactions of pyrethroid insecticides with insect ion channels
title_full_unstemmed Molecular interactions of pyrethroid insecticides with insect ion channels
title_sort molecular interactions of pyrethroid insecticides with insect ion channels
publisher University of Nottingham
publishDate 2008
url http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.495529
work_keys_str_mv AT verdinpaulstephen molecularinteractionsofpyrethroidinsecticideswithinsectionchannels
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