The role of n-linked glycosylation and sialylation in regulating human proteinase-activated receptor 1 and 4 expression and signalling

The role of n-linked glycosylation and sialylation in regulating human proteinase-activated receptor 1 and 4 expression and signalling

Proteinase-activated receptors (PARs) are a novel family of G-protein coupled receptors (GPCRs) that mediate many of the diverse biological effects of proteinases on target cells. N-linked glycosylation is a common post-translational modification in the GPCR superfamily that enables the cell to regu...

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Bibliographic Details
Main Author: Xiao, Yu Pei
Other Authors: Compton, Steven J. ; Morice, Alyn H.
Published: University of Hull 2008
Subjects:
612.01575
Medicine
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494884
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spelling ndltd-bl.uk-oai-ethos.bl.uk-4948842016-12-08T03:17:01ZThe role of n-linked glycosylation and sialylation in regulating human proteinase-activated receptor 1 and 4 expression and signallingXiao, Yu PeiCompton, Steven J. ; Morice, Alyn H.2008Proteinase-activated receptors (PARs) are a novel family of G-protein coupled receptors (GPCRs) that mediate many of the diverse biological effects of proteinases on target cells. N-linked glycosylation is a common post-translational modification in the GPCR superfamily that enables the cell to regulate protein function without recourse to the genome. Previous pharmacological studies have found that activation of hPAR-2 by mast cell tryptase can be regulated by receptor N-terminal glycosylation. However, the role of N-linked glycosylation in regulating the expression and function of other PARs is not known.612.01575MedicineUniversity of Hullhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494884http://hydra.hull.ac.uk/resources/hull:1695Electronic Thesis or Dissertation
collection NDLTD
sources NDLTD
topic 612.01575
Medicine
spellingShingle 612.01575
Medicine
Xiao, Yu Pei
The role of n-linked glycosylation and sialylation in regulating human proteinase-activated receptor 1 and 4 expression and signalling
description Proteinase-activated receptors (PARs) are a novel family of G-protein coupled receptors (GPCRs) that mediate many of the diverse biological effects of proteinases on target cells. N-linked glycosylation is a common post-translational modification in the GPCR superfamily that enables the cell to regulate protein function without recourse to the genome. Previous pharmacological studies have found that activation of hPAR-2 by mast cell tryptase can be regulated by receptor N-terminal glycosylation. However, the role of N-linked glycosylation in regulating the expression and function of other PARs is not known.
author2 Compton, Steven J. ; Morice, Alyn H.
author_facet Compton, Steven J. ; Morice, Alyn H.
Xiao, Yu Pei
author Xiao, Yu Pei
author_sort Xiao, Yu Pei
title The role of n-linked glycosylation and sialylation in regulating human proteinase-activated receptor 1 and 4 expression and signalling
title_short The role of n-linked glycosylation and sialylation in regulating human proteinase-activated receptor 1 and 4 expression and signalling
title_full The role of n-linked glycosylation and sialylation in regulating human proteinase-activated receptor 1 and 4 expression and signalling
title_fullStr The role of n-linked glycosylation and sialylation in regulating human proteinase-activated receptor 1 and 4 expression and signalling
title_full_unstemmed The role of n-linked glycosylation and sialylation in regulating human proteinase-activated receptor 1 and 4 expression and signalling
title_sort role of n-linked glycosylation and sialylation in regulating human proteinase-activated receptor 1 and 4 expression and signalling
publisher University of Hull
publishDate 2008
url http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494884
work_keys_str_mv AT xiaoyupei theroleofnlinkedglycosylationandsialylationinregulatinghumanproteinaseactivatedreceptor1and4expressionandsignalling
AT xiaoyupei roleofnlinkedglycosylationandsialylationinregulatinghumanproteinaseactivatedreceptor1and4expressionandsignalling
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