Molecular mechanisms by which flavonoids confer improved endothelial function and reduced risk of cardiovascular disease
Several epidemiological studies hove reported on inverse association between flavonoid intake and cardiovascular disease risk and mortality. Furthermore, acute ingestion of flavonoid-rich foods and beverages has been shown to improve parameters of endothelial function, a major cardiovascular disease...
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University of Reading
2008
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494803 |
| Summary: | Several epidemiological studies hove reported on inverse association between flavonoid intake and cardiovascular disease risk and mortality. Furthermore, acute ingestion of flavonoid-rich foods and beverages has been shown to improve parameters of endothelial function, a major cardiovascular disease risk factor and an early stage of atherogenesis. Here we report that flavonoids may improve endothelial function by 1) direct scavenging of the biologically relevant oxidant peroxynitrite, 2) preventing peroxynitrite-induced fibroblast injury via direct reaction with peroxynitrite and/or activation of pro-survival signalling, and 3) down-regulating inflammatory cytokine induced adhesion molecule expression (ICAM-l and VCAM-1). |
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