The role of DNMT1 inhibition in the identification of epigenetically silenced genes in pituitary tumours

The role of DNMT1 inhibition in the identification of epigenetically silenced genes in pituitary tumours

Epigenetic unmasking, either by pharmacological inhibition or direct gene targeting, has been utilised to identify novel tumour suppressor genes that are silenced in association with inappropriate CpG island (CGI) methylation in various types of cancer. In this study, an epigenetic unmasking strateg...

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Main Author: Dudley, Kevin
Published: Keele University 2009
Subjects:
616.47
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493649
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spelling ndltd-bl.uk-oai-ethos.bl.uk-4936492015-03-20T04:16:53ZThe role of DNMT1 inhibition in the identification of epigenetically silenced genes in pituitary tumoursDudley, Kevin2009Epigenetic unmasking, either by pharmacological inhibition or direct gene targeting, has been utilised to identify novel tumour suppressor genes that are silenced in association with inappropriate CpG island (CGI) methylation in various types of cancer. In this study, an epigenetic unmasking strategy was developed to identify novel genes that are silenced in association with inappropriate, CGI methylation in pituitary tumours.616.47Keele Universityhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493649Electronic Thesis or Dissertation
collection NDLTD
sources NDLTD
topic 616.47
spellingShingle 616.47
Dudley, Kevin
The role of DNMT1 inhibition in the identification of epigenetically silenced genes in pituitary tumours
description Epigenetic unmasking, either by pharmacological inhibition or direct gene targeting, has been utilised to identify novel tumour suppressor genes that are silenced in association with inappropriate CpG island (CGI) methylation in various types of cancer. In this study, an epigenetic unmasking strategy was developed to identify novel genes that are silenced in association with inappropriate, CGI methylation in pituitary tumours.
author Dudley, Kevin
author_facet Dudley, Kevin
author_sort Dudley, Kevin
title The role of DNMT1 inhibition in the identification of epigenetically silenced genes in pituitary tumours
title_short The role of DNMT1 inhibition in the identification of epigenetically silenced genes in pituitary tumours
title_full The role of DNMT1 inhibition in the identification of epigenetically silenced genes in pituitary tumours
title_fullStr The role of DNMT1 inhibition in the identification of epigenetically silenced genes in pituitary tumours
title_full_unstemmed The role of DNMT1 inhibition in the identification of epigenetically silenced genes in pituitary tumours
title_sort role of dnmt1 inhibition in the identification of epigenetically silenced genes in pituitary tumours
publisher Keele University
publishDate 2009
url http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493649
work_keys_str_mv AT dudleykevin theroleofdnmt1inhibitionintheidentificationofepigeneticallysilencedgenesinpituitarytumours
AT dudleykevin roleofdnmt1inhibitionintheidentificationofepigeneticallysilencedgenesinpituitarytumours
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