Evaluation of Bcl-2 Family Targeting Therapeutics in neuroblastoma
Neuroblastoma is the commonest extracranial solid tumour of childhood and often has a poor outcome. Resistance to chemotherapy is a common problem and despite advances in treatment over recent years new strategies are needed. The aim of this project was an investigation of hypoxia mediated drug resi...
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University of Manchester
2008
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493457 |
| Summary: | Neuroblastoma is the commonest extracranial solid tumour of childhood and often has a poor outcome. Resistance to chemotherapy is a common problem and despite advances in treatment over recent years new strategies are needed. The aim of this project was an investigation of hypoxia mediated drug resistance in neuroblastoma and the characterisation of the novel apoptosis based therapeutic ABT-737. |
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