Cell signalling pathways and clinical outcome of oxidative stress inhibitiors in acute pancreatitis

Cell signalling pathways and clinical outcome of oxidative stress inhibitiors in acute pancreatitis

Contemporary theories regard that systemic inflammatory response in acute pancreatitis is elicited by the secretion of the pro-inflammatory cytokines, leukocytes activation and their interaction with the activated vascular endothelium. There is increasing evidence of the role of acinar cell injury a...

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Main Author: Virlos, Ioannis Theodore
Published: University of Manchester 2008
Subjects:
616.37061
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493420
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spelling ndltd-bl.uk-oai-ethos.bl.uk-4934202017-12-24T16:32:19ZCell signalling pathways and clinical outcome of oxidative stress inhibitiors in acute pancreatitisVirlos, Ioannis Theodore2008Contemporary theories regard that systemic inflammatory response in acute pancreatitis is elicited by the secretion of the pro-inflammatory cytokines, leukocytes activation and their interaction with the activated vascular endothelium. There is increasing evidence of the role of acinar cell injury and oxidative stress injury as key events of localised pancreatic response in acute pancreatitis, which triggers the production of pro-inflammatory cytokines and subsequently the escalation of systemic inflammatory response and remote organ dysfunction. The aim of this thesis is to assess the role of anti-oxidant supplementation in the outcome of severe acute pancreatitis and to investigate the effect of a central inflammatory pathway inhibition in acute pancreatitis.616.37061University of Manchesterhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493420Electronic Thesis or Dissertation
collection NDLTD
sources NDLTD
topic 616.37061
spellingShingle 616.37061
Virlos, Ioannis Theodore
Cell signalling pathways and clinical outcome of oxidative stress inhibitiors in acute pancreatitis
description Contemporary theories regard that systemic inflammatory response in acute pancreatitis is elicited by the secretion of the pro-inflammatory cytokines, leukocytes activation and their interaction with the activated vascular endothelium. There is increasing evidence of the role of acinar cell injury and oxidative stress injury as key events of localised pancreatic response in acute pancreatitis, which triggers the production of pro-inflammatory cytokines and subsequently the escalation of systemic inflammatory response and remote organ dysfunction. The aim of this thesis is to assess the role of anti-oxidant supplementation in the outcome of severe acute pancreatitis and to investigate the effect of a central inflammatory pathway inhibition in acute pancreatitis.
author Virlos, Ioannis Theodore
author_facet Virlos, Ioannis Theodore
author_sort Virlos, Ioannis Theodore
title Cell signalling pathways and clinical outcome of oxidative stress inhibitiors in acute pancreatitis
title_short Cell signalling pathways and clinical outcome of oxidative stress inhibitiors in acute pancreatitis
title_full Cell signalling pathways and clinical outcome of oxidative stress inhibitiors in acute pancreatitis
title_fullStr Cell signalling pathways and clinical outcome of oxidative stress inhibitiors in acute pancreatitis
title_full_unstemmed Cell signalling pathways and clinical outcome of oxidative stress inhibitiors in acute pancreatitis
title_sort cell signalling pathways and clinical outcome of oxidative stress inhibitiors in acute pancreatitis
publisher University of Manchester
publishDate 2008
url http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493420
work_keys_str_mv AT virlosioannistheodore cellsignallingpathwaysandclinicaloutcomeofoxidativestressinhibitiorsinacutepancreatitis
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