Hepatitis C: genetic and host factors associated with outcome following infection

• Main Author: Price, David Ashley
• Published: University of Newcastle Upon Tyne 2008
• Subjects: 616.362307
• Online Access: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493078

Data on 1113 patients was collected and entered into a database. The North East cohort of patients infected with HCV were not different from other cohorts. Risks for progression of liver disease of heavy alcohol use, male sex and length of time of infection were similar to those reported in other national cohorts. A major effect of HCV on lipid homeostasis was seen in this cohort. The rate of steatosis amongst patients with chronic HCV infection was 50% similar to other studies and it would appear that a high BMl and viral genotype were the most important factors in the development of steatosis in this cohort. As in other studies hypolipidaemia was also seen in those with chronic HCV infection and this appeared to resolve with treatment.