Physiologically-based Pharmacokinetic Modelling:Pre-clinical and Clinical Pharnmacokinetic Studies

Physiologically-based Pharmacokinetic Modelling:Pre-clinical and Clinical Pharnmacokinetic Studies

Physiologically-based pharmacokinetic (PBPK) modelling is a computational technique which includes the anatomy and physiology of the study species (species-specific information), as well as the physicochemical properties of the study compound (compound-specific informafion). This data-rich situation...

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Main Author: Rodrigues, Clare Louise
Published: University of Manchester 2008
Subjects:
615.7
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492740
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spelling ndltd-bl.uk-oai-ethos.bl.uk-4927402015-03-20T05:16:55ZPhysiologically-based Pharmacokinetic Modelling:Pre-clinical and Clinical Pharnmacokinetic StudiesRodrigues, Clare Louise2008Physiologically-based pharmacokinetic (PBPK) modelling is a computational technique which includes the anatomy and physiology of the study species (species-specific information), as well as the physicochemical properties of the study compound (compound-specific informafion). This data-rich situation confers many advantages on drug development and discovery, especially in the areas of extrapolation between species, route IS of administration and doses. However, it remains under-used in drug research. This thesis examines the applications of PBPK modelling in three different scenarios, in the light of recent developments in this field, in order to support its wider use in drug research in both preclinical and clinical areas.615.7University of Manchesterhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492740Electronic Thesis or Dissertation
collection NDLTD
sources NDLTD
topic 615.7
spellingShingle 615.7
Rodrigues, Clare Louise
Physiologically-based Pharmacokinetic Modelling:Pre-clinical and Clinical Pharnmacokinetic Studies
description Physiologically-based pharmacokinetic (PBPK) modelling is a computational technique which includes the anatomy and physiology of the study species (species-specific information), as well as the physicochemical properties of the study compound (compound-specific informafion). This data-rich situation confers many advantages on drug development and discovery, especially in the areas of extrapolation between species, route IS of administration and doses. However, it remains under-used in drug research. This thesis examines the applications of PBPK modelling in three different scenarios, in the light of recent developments in this field, in order to support its wider use in drug research in both preclinical and clinical areas.
author Rodrigues, Clare Louise
author_facet Rodrigues, Clare Louise
author_sort Rodrigues, Clare Louise
title Physiologically-based Pharmacokinetic Modelling:Pre-clinical and Clinical Pharnmacokinetic Studies
title_short Physiologically-based Pharmacokinetic Modelling:Pre-clinical and Clinical Pharnmacokinetic Studies
title_full Physiologically-based Pharmacokinetic Modelling:Pre-clinical and Clinical Pharnmacokinetic Studies
title_fullStr Physiologically-based Pharmacokinetic Modelling:Pre-clinical and Clinical Pharnmacokinetic Studies
title_full_unstemmed Physiologically-based Pharmacokinetic Modelling:Pre-clinical and Clinical Pharnmacokinetic Studies
title_sort physiologically-based pharmacokinetic modelling:pre-clinical and clinical pharnmacokinetic studies
publisher University of Manchester
publishDate 2008
url http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492740
work_keys_str_mv AT rodriguesclarelouise physiologicallybasedpharmacokineticmodellingpreclinicalandclinicalpharnmacokineticstudies
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