Nuclear mitochondrial interactions in human disease
The maintenance of mitochondrial DNA (mtDNA) is dependent on DNA polymerase gamma (poly). The catalytic subunit encoded by the POLG1 gene has become the target for much investigation. Reported mutations result in disrupted mtDNA maintenance leading to a quantitative (depletion) or qualitative (point...
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University of Newcastle Upon Tyne
2008
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492095 |