Understanding the role of fibripositors in collagen biosynthesis
Cells in embryonic tendon deposit parallel arrays of narrow-diameter collagen fibrils that form a template parallel arrangement of the fibrils is established during mid-embryonic development when the tendon anlagen is formed by cadherin-11-influenced condensation of pre-tendon mesenchyme. It is wide...
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University of Manchester
2008
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491847 |
| Summary: | Cells in embryonic tendon deposit parallel arrays of narrow-diameter collagen fibrils that form a template parallel arrangement of the fibrils is established during mid-embryonic development when the tendon anlagen is formed by cadherin-11-influenced condensation of pre-tendon mesenchyme. It is widely accepted that the assembly, parallelism and packing collagen fibrils is cell mediated however the molecular and cellular mechanisms are unknown. Recent evidence from the Kadler group supports a new model for the orchestration of collagen fibril assembly and organisation during late embryonic development. |
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