Pyrazolopyridines as phosphodiesterase inhibitors for respiratory disease
Synthetic chemistry was explored to expand a series of 6-(pyrazolo[1,5-a]pyridin-3-yl)-2Hpyridazin- 3-one phosphodiesterase (PDE) inhibitors with therapeutic potential for treatment of asthma. The synthetic route to these compounds featured a 1,3-dipolar cycloaddition reaction between a pyridine N-i...
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Heriot-Watt University
2007
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490952 |