Characterisation of the Vertabrate inner-retinal photiopigments melanapsin (Opn4) and vertebrate ancient(VA) opsin

Characterisation of the Vertabrate inner-retinal photiopigments melanapsin (Opn4) and vertebrate ancient(VA) opsin

The most robust entrainment cue to the circadian clock is light. In response to this, organisms have evolved light detection mechanisms which allow them to measure and transduce irradiance information to specific centres in the brain. To perceive light, these receptors use photosensitive opsins that...

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Bibliographic Details
Main Author: Pires, Susana Salgado
Published: University of Oxford 2008
Subjects:
573.88
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490346
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spelling ndltd-bl.uk-oai-ethos.bl.uk-4903462015-03-20T06:27:55ZCharacterisation of the Vertabrate inner-retinal photiopigments melanapsin (Opn4) and vertebrate ancient(VA) opsinPires, Susana Salgado2008The most robust entrainment cue to the circadian clock is light. In response to this, organisms have evolved light detection mechanisms which allow them to measure and transduce irradiance information to specific centres in the brain. To perceive light, these receptors use photosensitive opsins that are remarkably divergent from those involved in image-forming photoreception. The main focus of this work was to understand if the photopigment function of the inner-retinal opsins can be inferred from their sequence and predicted structure. To this end we have isolated and characterised melanopsin and VA opsin from vertebrate species that have evolved under different environments.573.88University of Oxfordhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490346Electronic Thesis or Dissertation
collection NDLTD
sources NDLTD
topic 573.88
spellingShingle 573.88
Pires, Susana Salgado
Characterisation of the Vertabrate inner-retinal photiopigments melanapsin (Opn4) and vertebrate ancient(VA) opsin
description The most robust entrainment cue to the circadian clock is light. In response to this, organisms have evolved light detection mechanisms which allow them to measure and transduce irradiance information to specific centres in the brain. To perceive light, these receptors use photosensitive opsins that are remarkably divergent from those involved in image-forming photoreception. The main focus of this work was to understand if the photopigment function of the inner-retinal opsins can be inferred from their sequence and predicted structure. To this end we have isolated and characterised melanopsin and VA opsin from vertebrate species that have evolved under different environments.
author Pires, Susana Salgado
author_facet Pires, Susana Salgado
author_sort Pires, Susana Salgado
title Characterisation of the Vertabrate inner-retinal photiopigments melanapsin (Opn4) and vertebrate ancient(VA) opsin
title_short Characterisation of the Vertabrate inner-retinal photiopigments melanapsin (Opn4) and vertebrate ancient(VA) opsin
title_full Characterisation of the Vertabrate inner-retinal photiopigments melanapsin (Opn4) and vertebrate ancient(VA) opsin
title_fullStr Characterisation of the Vertabrate inner-retinal photiopigments melanapsin (Opn4) and vertebrate ancient(VA) opsin
title_full_unstemmed Characterisation of the Vertabrate inner-retinal photiopigments melanapsin (Opn4) and vertebrate ancient(VA) opsin
title_sort characterisation of the vertabrate inner-retinal photiopigments melanapsin (opn4) and vertebrate ancient(va) opsin
publisher University of Oxford
publishDate 2008
url http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490346
work_keys_str_mv AT piressusanasalgado characterisationofthevertabrateinnerretinalphotiopigmentsmelanapsinopn4andvertebrateancientvaopsin
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