Design, synthesis and biological evaluation of heparin/heparan sulfate analogues as inhibitors of GAG-growth factor interaction

Design, synthesis and biological evaluation of heparin/heparan sulfate analogues as inhibitors of GAG-growth factor interaction

Control of cell proliferation is of fundamental importance to cancer chemotherapy. One of the key signalling events leading to cellular activities (i.e. cell division, proliferation, migration) involves Growth Factors such as Hepatocyte Growth Factor/Scatter Factor (HGF/SF) and Fibroblast Growth Fac...

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Main Author: Raiber, Eun-Ang
Published: University of Salford 2007
Subjects:
571.849
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490260
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spelling ndltd-bl.uk-oai-ethos.bl.uk-4902602015-03-20T05:04:15ZDesign, synthesis and biological evaluation of heparin/heparan sulfate analogues as inhibitors of GAG-growth factor interactionRaiber, Eun-Ang2007Control of cell proliferation is of fundamental importance to cancer chemotherapy. One of the key signalling events leading to cellular activities (i.e. cell division, proliferation, migration) involves Growth Factors such as Hepatocyte Growth Factor/Scatter Factor (HGF/SF) and Fibroblast Growth Factors (FGFs). They bind to specific transmembrane tyrosine kinase receptors at the cell surface. This can only take place in the presence of heparin and heparan sulfate proteoglycans. The literature in this area is reviewed.571.849University of Salfordhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490260Electronic Thesis or Dissertation
collection NDLTD
sources NDLTD
topic 571.849
spellingShingle 571.849
Raiber, Eun-Ang
Design, synthesis and biological evaluation of heparin/heparan sulfate analogues as inhibitors of GAG-growth factor interaction
description Control of cell proliferation is of fundamental importance to cancer chemotherapy. One of the key signalling events leading to cellular activities (i.e. cell division, proliferation, migration) involves Growth Factors such as Hepatocyte Growth Factor/Scatter Factor (HGF/SF) and Fibroblast Growth Factors (FGFs). They bind to specific transmembrane tyrosine kinase receptors at the cell surface. This can only take place in the presence of heparin and heparan sulfate proteoglycans. The literature in this area is reviewed.
author Raiber, Eun-Ang
author_facet Raiber, Eun-Ang
author_sort Raiber, Eun-Ang
title Design, synthesis and biological evaluation of heparin/heparan sulfate analogues as inhibitors of GAG-growth factor interaction
title_short Design, synthesis and biological evaluation of heparin/heparan sulfate analogues as inhibitors of GAG-growth factor interaction
title_full Design, synthesis and biological evaluation of heparin/heparan sulfate analogues as inhibitors of GAG-growth factor interaction
title_fullStr Design, synthesis and biological evaluation of heparin/heparan sulfate analogues as inhibitors of GAG-growth factor interaction
title_full_unstemmed Design, synthesis and biological evaluation of heparin/heparan sulfate analogues as inhibitors of GAG-growth factor interaction
title_sort design, synthesis and biological evaluation of heparin/heparan sulfate analogues as inhibitors of gag-growth factor interaction
publisher University of Salford
publishDate 2007
url http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490260
work_keys_str_mv AT raibereunang designsynthesisandbiologicalevaluationofheparinheparansulfateanaloguesasinhibitorsofgaggrowthfactorinteraction
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