The development of small molecule anatagonists of the MDM2-p53 binding interaction
The MDM2 oncoprotein and the p53 tumour suppressor form an autoregulatory loop in normal cells. The MDlvI2 gene is a target for direct transcriptional activation by p53, while the MDM2 protein binds and negatively regulates the transcriptional activity of p53, as well as targeting it for proteasomal...
| Main Author: | |
|---|---|
| Published: |
University of Newcastle upon Tyne
2005
|
| Subjects: | |
| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490151 |