The role of galectin-1 in skeletal muscle development and regeneration
Galectin-1 is a p-galactoside binding lectin that has been implicated in a variety of cellular processes in different tissues, including skeletal muscle. Initial studies investigating the phenotype of a null mouse model for galectin-1 suggested that there were no obvious differences between the musc...
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University of Sussex
2007
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.488604 |
| Summary: | Galectin-1 is a p-galactoside binding lectin that has been implicated in a variety of cellular processes in different tissues, including skeletal muscle. Initial studies investigating the phenotype of a null mouse model for galectin-1 suggested that there were no obvious differences between the musculature of the null mouse and that of the wild-type mouse. However, in vitro studies suggested that the addition of galectin-1 Improved the fusion of myoblasts to myotubes and caused dermal fibroblasts to convert to the myogenic lineage. |
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