An investigation of DNA sequence variants of unknown significance in hereditary breast cancer
Inheritance of a protein truncating mutation of the tumour suppressor gene BRCA1 causes approximately 5% of breast tumours. Over 450 distinct BRCA1 missense mutations have also been found in patients with a family history of breast cancer and the functional significance of most of these is unclear....
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University of Southampton
2007
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485037 |