Production of HIV-2 envelope glycoproteins for structural and functional studies

Production of HIV-2 envelope glycoproteins for structural and functional studies

Envelope glycoproteins of HIV-1 (gp160 > gp120/41) and HIV-2 (gp140 > gp105/36) have -40% sequence identity, bind cell surface receptors (CD4 and CCR5 or CXCR4) and effect membrane fusion, suggesting a close structural similarity. HIV-2 gp140 is more stable than HIV-1 gp160 (Sattentau et al.,...

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Bibliographic Details
Main Author:	Halley, Jennifer Mary
Published:	University College London (University of London) 2007
Subjects:	616.9792
Online Access:	http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444203

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