Production of HIV-2 envelope glycoproteins for structural and functional studies
Envelope glycoproteins of HIV-1 (gp160 > gp120/41) and HIV-2 (gp140 > gp105/36) have -40% sequence identity, bind cell surface receptors (CD4 and CCR5 or CXCR4) and effect membrane fusion, suggesting a close structural similarity. HIV-2 gp140 is more stable than HIV-1 gp160 (Sattentau et al.,...
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University College London (University of London)
2007
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444203 |